New Alzheimer’s Treatment Fully Restores Memory Function For Mice

New submitter wrp103 writes Australian researchers have come up with a non-invasive ultrasound technology [abstract] that clears the brain of neurotoxic amyloid plaques — structures that are responsible for memory loss and a decline in cognitive function in Alzheimer’s patients. A slice: Publishing in Science Translational Medicine, the team describes the technique as using a particular type of ultrasound called a focused therapeutic ultrasound, which non-invasively beams sound waves into the brain tissue. By oscillating super-fast, these sound waves are able to gently open up the blood-brain barrier, which is a layer that protects the brain against bacteria, and stimulate the brain’s microglial cells to move in. Microglila cells are basically waste-removal cells, so once they get past the blood-brain barrier, they’re able to clear out the toxic beta-amyloid clumps before the blood-brain barrier is restored within a few hours. The team reports fully restoring the memories of 75 percent of the mice they tested it on, with zero damage to the surrounding brain tissue. They found that the treated mice displayed improved performance in three memory tasks – a maze, a test to get them to recognise new objects, and one to get them to remember the places they should avoid.

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New Alzheimer’s Treatment Fully Restores Memory Function For Mice

If You Try the HTML5 Drum Machine, It’s All You’ll Do for the Next Hour

If You Try the HTML5 Drum Machine, It's All You'll Do for the Next Hour

This dead simple drum machine that runs in your browser is so much fun.

The HTML5 Drum Machine borrows its aesthetics from classic beat boxes like the TR-808 Rhythm Composer. It’s got five different sound banks: Hip hop, electro, house, techno, and acoustic. Each bank has 13 different sounds for which you can tweak the individual volume and tone. Pick your bank, hit play, and lay down your instruments on the 16-step sequencer interface that runs across the bottom. After you’ve laid down your beat, you can export it as a Wav.

Even if you don’t have any experience with drum machines, this simplified beat maker is intuitive enough that you’ll impress yourself within just a few minutes. You can probably figure it out on your own, but if you’re a total noob here’s a tip: The important thing to remember is that for each of the 16 "steps" in the sequence you can play each of the 13 sounds in a bank. So when you click on one sound—say the Kick— you can place that sound in any or all of the 16 slots. When you click on the next instrument, you again have the option of sticking it in all of the 16 slots.

Drum machines and software instruments can both be really intimidating to the uninitiated. The HTML 5 Drum Machine is simplified that basically anybody can get going. [HTML 5 Drum Machine via Synthtopia]

via Gizmodo
If You Try the HTML5 Drum Machine, It’s All You’ll Do for the Next Hour

What to Do When a Co-Worker Becomes Your New Boss

What to Do When a Co-Worker Becomes Your New Boss

So, there you are: It’s that awkward moment when you’re told that a fellow colleague is now your new boss. Your mind races as the news sinks in. As you hide your initial shock and force a smile you can’t help but wonder—my lunch buddy is becoming my manager. Now what?

This post originally appeared on The Muse.

Or, you’re on the other side of the equation: You’ve just been promoted, and you know your role in the team dynamic will shift. Now, you are now the one calling the shots.

If you’ve ever experienced either position, you’re not alone. Navigating change at work can be tough, especially when it comes to restructuring. So how do you handle the transition? Here are a few steps to do it gracefully.

If You’re the New Manager

What to Do When a Co-Worker Becomes Your New Boss

Let’s start with newly appointed managers. As a leader among your former peers, your actions will speak louder than words. Begin your tenure by taking four actions to send all the right messages.

1. Tell Your Team

View telling your team about your step up not as a dreaded moment, but as an opportunity. Communicate with honesty about your new role, and share news ofyour promotion formally and in a way that will reach the entire team at once (i.e., no more going to your office BFF first, which could now be read as playing favorites).

Telling everyone together demonstrates that you will work to ensure equity for your team—and avoids any skepticism stemming from former colleagues hearing the information from someone other than you. Avoid this risk and establish what kind of leader you’ll be by being upfront with your entire team.

2. Get Their Endorsement

Is your team willing to trust you as their leader? To gauge this upfront, set up one-on-one meetings, and use them as an opportunity to ask direct reports if they are prepared to support you—or if they have any questions or concerns they’d like to discuss.

Asking for their endorsement may seem redundant or unnecessary (you were promoted, after all). But as every major airline knows, unless you directly ask someone if she is willing and able to open the emergency door, there is a chance that she won’t.

If someone isn’t supportive, ask him for a plan for how he might get on board. This is for his benefit—not yours. Helping him establish a plan to cope with the transition will benefit his career and is exactly what a strong manager would do.

3. Don’t Soften the Message, Up the Support

New leaders—particularly when they’re leading their former peers—often try to buy people’s love by softening their message. They may be less ambitious in the goals and expectations they set to ease transition. Avoid this temptation, and “up” the support instead! Rather than dismissing your team’s concerns, be honest. Let them know that change can be challenging at times, but that the success of the transition is largely dependent on each individual.

Use group time to ask for input on these three questions:

  1. What do you want in your workplace?
  2. What are you willing to do to get it?
  3. How can I support it?

While you can’t necessarily make the transition easier on your team, you can help them find ways to succeed in their new reality.

4. Encourage Your Employees

Even if you used to gossip by the water cooler with your work buddies, don’t let your new office be a portal for drama. If there is a line of people waiting with lists of issues for you to fix, resist the urge to react immediately. Listen, but don’t commit to fixing all of their problems.

Maintain a positive response of “duly noted” or “good to know,” and set up processing sessions. Avoid pushing your own solutions (a common new manager mistake), and instead, be a sounding board and guide your team in determining how they will reach their goals given their circumstances. This will empower your employees to generate results.

If You’re the Employee Whose Colleague is Now the Boss

What to Do When a Co-Worker Becomes Your New Boss

Are you at the other end of the spectrum? As an employee, remember that you alone have the power to make this transition a career-limiting or career-enhancing experience through your actions. Here are four ways to make the most of the situation.

1. Step Up

No matter how you feel about your colleague becoming your new boss, it’s important to buy in early and show that you’re a willing partner. Embrace the situation and get on his calendar. Tell your boss that you are on board with the new team structure, and ask how you can support him during the transition. Your actions and outlook are huge indicators of whether you’ll succeed moving forward.

2. Follow Your Boss’ Example

One thing’s for sure, your co-worker did something right, or else she wouldn’t have been promoted! So stop questioning why it was her (instead of you) and follow her example.

Use this as an opportunity to clean up your behavior. Ditch the jealousy, and look to your new manager as a role model. How is she delivering on what the company values? Do what your new manager did, and you might see the same rewards.

3. Accept Reality

You could see your colleague beating you out for a promotion as a setback—or as a decision that’s already been made. So avoid negative self-talk and use your energy to answer the question, “How can I improve?”

An “I’m not good enough” mindset—not your circumstances—is what’s holding you back. Adopting a fresh outlook and redirecting your energy will make all the difference. You may even find you prefer your co-worker to your old boss!

4. Change the Conversation

If you hear fellow colleagues complaining, change the energy of the conversation. Say something sincere and positive about your new leader. Then, ask everyone involved about how they can help to mitigate their own fears or complaints. After all, you never know when you could be next in line for that big promotion.

What to Do When Your Co-Worker Becomes the Boss (or You Do) | The Muse


Cy Wakeman is a national keynote speaker, business consultant, New York Times bestselling author, blogger and trainer who has spent over 20 years cultivating a revolutionary, reality-based approach to leadership. For more on Cy, check out RealityBasedLeadership.com or follow her on Facebook, Twitter, LinkedIn and Instagram.

Image by ratch (Shutterstock). Additional photos by Kumar Appaiah and Alper Çuğun (Flickr). Want to see your work on Lifehacker? Email Andy.


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What to Do When a Co-Worker Becomes Your New Boss

Disable YouTube’s New AutoPlay Feature with This Button

Disable YouTube's New AutoPlay Feature with This Button

YouTube has quietly been rolling out a new feature that will automatically play the next suggested video when the current one you’re watching is done. Here’s how to disable it.

At the very top of the suggested videos (which may be next to your video or just below it, depending on the size of your player), there’s a blue button that says Autoplay. This button is in the same space that YouTube’s ads usually go, so you might already be trained to ignore it. Simply click this button and videos should stop autoplaying.

How To Disable The New Autoplay Feature On YouTube | Addictive Tips


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Disable YouTube’s New AutoPlay Feature with This Button

Seven Questions About the Second Amendment Answered

51941

Kenneth Roberts, “a 92-year-old World War II US Navy veteran” recently had a letter to the editor published in the Las Vegas Informer. Appropriately titled Questioning the Second Amendment, he poses seven questions designed to demonstrate, despite all evidence … Read More

The post Seven Questions About the Second Amendment Answered appeared first on The Truth About Guns.

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Seven Questions About the Second Amendment Answered

Somehow, Avengers: Age Of Ultron Saved The Awesomest Trailer For Last

To be fair, this is actually a new TV spot, not a full trailer. But something tels me that really won’t bother you much when this unbelievably amazing new batch of footage kicks your ass. You don’t believe me? Go ahead and watch.

See?! We‘re a little worried that Avengers: Age of Ultron is revealing too much footage, but it’s really hard not to stay excited when Thor hits Cap’s shield with his hammer and knocks it through Ultron minions like they were butter. May 1st, guys. A month and a half to go.

via Gizmodo
Somehow, Avengers: Age Of Ultron Saved The Awesomest Trailer For Last

A Locking Knife Block Keeps Your Blades Inaccessible to Kids

A Locking Knife Block Keeps Your Blades Inaccessible to Kids

When you’re bustling in the kitchen prepping a meal, quickly grabbing a knife out of a storage block is easier than digging through a drawer to find one. Storing them in a block is also just a better way to keep your knives sharp and in good shape, but it unfortunately means they’re easily accessible to children. So Joseph Joseph has incorporated a locking mechanism into its new LockBlock that makes knives harder for kids to remove.

A Locking Knife Block Keeps Your Blades Inaccessible to Kids

You’ll actually need a pair of adult-sized hands to operate the block’s stiff blade release which helps to make it kid-proof. And each knife is locked in place with a clever "Cam-lock mechanism" that increases the grip the harder a knife is pulled, making them all but impossible to remove using just brute force.

The LockBlock itself, with universal slots that will accommodate your existing knives, is available now for $60. But there’s also a $150 version that comes with six knives of its own and slots custom-sized to fit each one if you’re just starting to outfit your kitchen.

[Joseph Joseph via Fancy]

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A Locking Knife Block Keeps Your Blades Inaccessible to Kids

Mini Excel Tutorial: Using Advanced Counting and Adding Functions in Excel

excel-advanced-count

Excel formulas can do a lot of really great things, from helping you get your finances together to helping manage your entire life. You might think of counting and adding formulas as relatively mundane compared to more advanced formulas that are out there, but having a good handle on these functions can help you save a lot of time when you need to collect information about the data in your spreadsheet. COUNT The COUNT function counts the number of cells in a range that have numbers in them. If you use a formula to run a lot of calculations, you may find yourself…

Read the full article: Mini Excel Tutorial: Using Advanced Counting and Adding Functions in Excel

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Mini Excel Tutorial: Using Advanced Counting and Adding Functions in Excel

Flesh-Detecting Saw Instantly Drops the Blade Without Destroying It

Flesh-Detecting Saw Instantly Drops the Blade Without Destroying It

Close to a decade ago a clever inventor came up with a safety feature for power tools that could detect when a blade made contact with human flesh and instantly retract it to prevent injury. Unfortunately, it destroyed the tool in the process.

The SawStop technology was amazing, and probably life-saving, but it left a lot of people without saws. Bosch’s new REAXX Portable Jobsite Table Saw does the exact same thing, except that it can be reset to working order again in just 60 seconds.

The secret to the saw’s near-instant reaction time is an explosive cartridge that’s triggered when the saw blade detects the conductivity of human flesh. Sort of like how your smartphone’s display is able to detect your fingers. The blade is instantly retracted into the table saw preventing serious physical injury, but without warping, bending, or permanently damaging it in any way. And it has all the tools built-in needed to flip the two-shot cartridge around and get back to work in about 60 seconds.

The REAXX table saw also has a series of easy-to-understand LED warning lights letting the operator know if it’s safe to operate. And the flesh-detecting system can be temporarily de-activated when cutting conductive materials that might accidentally trigger it. It will be available this fall for $1,500, and while there’s no word on how much the replacement cartridges will sell for, the fact that they actually exist is what’s important here. Because last we checked, finger replacements aren’t yet available. [Bosch]

Flesh-Detecting Saw Instantly Drops the Blade Without Destroying It

Flesh-Detecting Saw Instantly Drops the Blade Without Destroying It

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Flesh-Detecting Saw Instantly Drops the Blade Without Destroying It