Best Concealed Carry Guns (By Popular Caliber) [2018]

What is the best caliber for concealed carry?

That’s the age-old question, isn’t it? When choosing a CCW, this is a good place to start.

Carrying a gun chambered in .45 ACP will be larger than one chambered in .380.  That’s just how it is and there is no way around it.

choosewiselymeme

By then end you’ll have a good understanding of the best caliber for you…

Concealed Carry, Shirtless
Concealed Carry

Plus our favorite concealed carry handguns for it!  And our favorite holsters and ammo too.

Table of Contents

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Variables to Consider

The size of your piece matters.

If you decide to go with a larger caliber or a double stacked magazine, your gun will be physically larger. If you have a thinner or smaller body or like to wear tighter clothing…the fact you’re carrying a gun will be VERY obvious.

Clothing

For those of us in the Midwest, we have, what seems like, 16 months of winter where we wear big jackets and sweatshirts. This allows us to carry just about any caliber CCW we want.

But, when summer rolls around, that changes. Carrying a full-size .45 ACP is more difficult to conceal in shorts and a t-shirt.

Conceal in winter clothing
At least it’s easier to conceal wearing winter clothing!

Take a look at your style and your seasons to find a good compromise. Possibly owning a gun for winter carry and another one for warmer months. Think of it as a seasonal accessory if it helps you justify the purchase.

Choosing the Caliber

There are a few ways to choose the caliber of your CCW. First is to ask around. My guess is you’ll get a lot of people replying that their carry gun is a 9mm or a .45 ACP. These are probably the most common.

Another way is to follow what law enforcement, military, and government agencies use. They tend to do a lot of research into what the bare minimum yet effective caliber or weapons are out there.

Caliber Comparison
The .380 looks like the 9mm’s younger sibling

What you will see with a lot of these groups is that they went back to 9mm.

This is because the 9mm has come a long way in the last few years. The .40 S&W was the go-to for a long time, but not really anymore. Something I noticed in my time building police vehicles was the rural departments, and many times sheriffs in rural areas carry .45 ACP.

Learn more about acceptable calibers in our Pistol Caliber Overview.

Carrying a .22LR

While a .22LR can deter an attacker, it is not really recommended for concealed carry. If this is your only option, then go for it. Something is better than nothing But, if you are going to purchase something to carry every day, go with a larger caliber.

shooting with a disability
.22lr revolvers like this one are often a great choice for disabled folks looking to defend themselves. Find more recommendations in our article for Disabled Shooters!

If you are in a state that has colder weather, a .22LR will have some difficulties penetrating thicker or multiple layers of clothing.

What is likely to happen if you were to use a .22LR and be forced to use it against an attacker wearing a thicker jacket (Carhartt or similar), is the bullet may pierce the jacket and clothing but could struggle to do the appropriate amount of damage needed to disable the attacker.

Check out our picks in Best .22s for Pocket Carry.

Best Concealed Carry Guns By Caliber

Below are a couple choices for each caliber to help get your search started.

I know everyone has their favorites and there will be comments about this gun or that gun should be on or off the list. Feel free to interject, but leave useful comments and suggestions.

9mm

The 9mm CCW category is packed with a lot of good choices. Also, keep in mind that most of the manufacturers make a .40 S&W and a 9mm in the same size frame so I am only listing the 9mm models here.

Smith & Wesson M&P Shield

What I like about the Smith & Wesson M&P Shield 9mm is it’s a good size to conceal and large enough to get your whole hand on the grip.

Smith & Wesson M&P Shield M2.0

Smith & Wesson M&P Shield M2.0

Prices accurate at time of writing

It’s smaller than a lot of compact guns but bigger than a subcompact. And it’s thin too. About 1” thick. The Shield and Shield 2.0 also come in a variety of calibers, too such as the Shield .380 Auto and Shield .45 ACP

If you’re interested in more information, we did a complete review of the S&W Performance Center M&P Shield!

SIG SAUER P365

They call this a “micro-compact.” For its size, it holds a lot of ammo. One of our favorites for 2018!

Most innovative CCW gun [2018]
Sig Sauer P365

Sig Sauer P365

Prices accurate at time of writing

I would compare it to a Glock 26 in size, but it holds 10+1 and is a single stack magazine. This keeps the width to an inch. It also has a rail if you want to add a light or other attachment.

While there have been some production issues of the P365 and some “voluntary” recalls, Sig Sauer seems to have ironed out the issues now.

Another PPT writer reviewed the Sig P365 not long ago and wrote a glowing review on it.

What’s your take on the P365?

Readers’ Ratings

5/5 (3)

Your Rating?

And for more 9mm specific CCW guns…check out Best Single Stack Sub-Compact 9mm.

.45 ACP

Something to note before you get your boxers in a bunch is I left out 1911s because this is an article about concealed carry.  We have our Best 1911s article for that.

Keep Calms and Concealed Carry On

Yes, you can carry a big gun if you want, but most want a smaller gun for their EDC.

Springfield Armory XD-S

The XD-S, even though it had some issues a while back, is a great choice for your CCW. The large caliber in the small frame is helpful.

Springfield XD(S) 3.3

Springfield XD(S) 3.3

Prices accurate at time of writing

It’s thin and easy to conceal, a combination that isn’t easy to find in a real larger caliber.

Because of the shorter barrel and the larger caliber, it kicks and can make reacquiring your target more difficult when firing quickly. You’ll probably need to train a little more with that than you would with a 9mm.  

But extra training should be assumed when you’re working with .45 ACP.

FN FNX-45

The FN FNX-45 is a bigger gun compared to some of the others listed so far. It is a compact size, so the barrel is a bit longer. If you are looking for something for your large hands, this would be a good option.

FNX-45

FNX-45

Prices accurate at time of writing

I got to shoot one of these and it was smooth for a compact 45. It was a little large for me to carry (I’m 5’11 170), but like the way it fired.

The FNX-45 also comes in a Tactical version that sports a threaded barrel, red dot mounting ability, a rail, and suppressor hight sights.

While highly impractical for CCW, it makes for an outstanding duty, open carry, and competition pistol.

FNX-45 Tactical

FNX-45 Tactical

Prices accurate at time of writing

Using one of each for your different needs makes it easier to transition between the two and makes training much simpler.

.380

A .380 is a very concealable weapon. They are usually thinner and smaller than a 9mm subcompact. You will lose some of the impact you get when a .380 hits the target, but they are still acceptable for self-defense.

You’ll want to read up on the differences and limitations of the .380 Auto, and we have Just the Article for You.

Same bullet, smaller casing.

Something you might want to look into right away if you are getting a .380 is a new trigger. Most of them have a long pull and can make them hard to shoot accurately under duress.

Ruger LCP II

The Ruger LCP II is a popular small gun and a large improvement over the older LCP model. It comes in different colors so finding the one you like aesthetically is easy.

Most Affordable .380 Pistol
Ruger LCP II .380

Ruger LCP II .380

Prices accurate at time of writing

Because of its size, the LCP II is a great “pocket” gun or even as a backup weapon. It has a 6+1 magazine which is pretty common for this size pistol.

We also have a complete review on the Ruger LCP II so you can learn all amount the pros and cons of this little guy.

Glock 42

The Glock 42 is a great choice if you are looking for a reliable single stack .380 or if you are Glock fan and want something a little smaller than their other offerings.

Most Reliable .380
Glock 42

Glock 42

Prices accurate at time of writing

Not a lot can be said, other than a thank you to Glock for starting to make some guns with a single stack magazine.

Besides that…it’s a Glock. Its bombproof, reliable, has massive aftermarket support, and people either hate it or love it.

For more .380…check out our 5 Best .380 Pistols for Concealed Carry.

.38 Special

A .38 Special or .38 special +P are very common calibers for revolvers and don’t really show up in semi-auto pistols. When it comes to a revolver for CCW, lightweight and hammerless are two of the characteristics I recommend looking into.

Bodyguard 38 Revolver Crimson Trace

Smith & Wesson makes a lot of revolvers and a lot of them have a .38 Special version.

Smith & Wesson M&P Bodyguard 38 Crimson Trace

Smith & Wesson M&P Bodyguard 38 Crimson Trace

Prices accurate at time of writing

S&W revolvers come in almost every shape, finish, size, and option you can think of. This one is super lightweight since it uses a one-piece aluminum frame and a very short barrel.

It’s handy, easy to use, and rated for +P. Everything you could want in a CCW revolver.

Ruger LCRx

The LCRx is a lightweight revolver from Ruger. An aluminum frame and some polymer parts make it a great carry gun.

Ruger LCRx

Ruger LCRx

Prices accurate at time of writing

It has an exposed hammer, so you’ll want to practice your draw to make sure you can do it well and not snag clothing. It’s also able to fire +P rounds for a little more punch.

If the exposed hammer is an issue for you though, Ruger also makes the LCR that uses an internal hammer for smoother draws.

Best Laser Equipped
Ruger LCR Revolver

Ruger LCR Revolver

Prices accurate at time of writing

For more .38 Special revolvers…check out 7 Best CCW .38 Revolvers.

Holsters, Belts, & Ammo

Going concealed with the perfect gun for you is still useless if you don’t have a great holster.  Check out our top holster picks for all the popular ways to carry.

Aliengear Holster, High Grip
Aliengear Holster, High Grip

Plus you’ll need a sturdy belt that doesn’t scream “I’m carrying a gun.”  Check out these nondescript options in Best CCW Gun Belts.

Best CCW Gun Belts, Thickness
Best CCW Gun Belts, Thickness

Same goes with ammo…we use data from shorter handguns and clothed ballistics gel to make our choices.  Since that’s what you’re likely to see in the real world.

Ballistics-Gel-Testing
Ballistics-Gel-Testing

See our self-defense and range ammo picks for all the popular calibers.

Final Thoughts

In this list, there are some popular models of various calibers to get you started in your search. Some are subcompact, some are not. In the .38 Special category, they are all revolvers and in the .45 ACP category, there are bigger guns.

Take a look at your lifestyle. This will have a big impact on what and when you will carry. Look for a CCW that will be convenient and comfortable to carry or you just won’t.

Comfort comes from how it fits your hand as well as how it feels carrying it on your person.

Just because you aren’t strapping a pair of 1911s in shoulder holsters every time you leave your man cave doesn’t mean you aren’t going to be safe. Get a 9mm or .380 that fits your hand and you can conceal in the majority of the clothing wear daily.

Lots of Holsters, Boondock Saints
Lots of Holsters, Boondock Saints

And as a reminder if you scan articles like I do: Everyone has their favorites and there will be comments about this gun or that gun should be on or off the list. Feel free to interject, but leave useful comments and suggestions.

We have some more specific articles too if you already know what you want:

We love to hear from our readers about their CCW choices, so let us know! What handgun do you use? What caliber? Tell us all about it in the comments!  And then head to our CCW Definitive Guide.

The post Best Concealed Carry Guns (By Popular Caliber) [2018] appeared first on Pew Pew Tactical.

via Pew Pew Tactical
Best Concealed Carry Guns (By Popular Caliber) [2018]

2018 Origin EON15-S Gaming Laptop

2018 Origin EON15-S Gaming Laptop

Price: $1449+  | Buy

The latest update to Origin’s light and slim gaming laptop sees thin bezels on its 1080p display, Intel 8th Gen CPUs, and a GeForce GTX 1050Ti or 1060 GPU. The 2018 EON15-S also has a USB-C port, two display ports, an HDMI port and individual RGB keyboard lighting.

via The Awesomer
2018 Origin EON15-S Gaming Laptop

CBF Morning Run: Throwing Pet Rocks at scooters and sipping Columbus Brewing Co.’s Insane Wanderer Vol. 1

Happy Wednesday morning, Columbus.
I’ve never been good with fads.
By the time I figure out whether I want to 1. ride a particular wave of popularity, and 2. pay for it, whatever it is usually has passed and another fad has taken its place.
For example, I bought an official Pet Rock in 1976. (The year, by the way, is important.)
For those of you who don’t remember Pet Rocks or are too young to have even heard of them, let me explain.
A man named Gary Dahl created the sensation when he began…

via Columbus Business News – Local Columbus News | Business First of Columbus
CBF Morning Run: Throwing Pet Rocks at scooters and sipping Columbus Brewing Co.’s Insane Wanderer Vol. 1

25 More Insanely Useful Websites You Might Need Someday

insanely-useful-websites

The internet is filled with websites. Billions of them. Some are useful, some, not so much. Some of the useful websites are quite popular, and rightly so—a tool like Canva is a life saver for easy web graphics. Then you have helpful tools like Down for Everyone or Just Me.

But there are many other useful websites beyond the ones you may know about. The fun is in discovering them. Fortunately, we went ahead and did the hard work for you.

1. Student.com

Student.com useful websites

If you are looking for cheap accommodation as an international student, this website helps you search for a home near your college/university or a neighborhood of your preference. The site covers around 400 cities and their service is for free!

2. Inner Body

Innerbody useful websites

The interactive guide to human anatomy. It is an easy way to study the human anatomy classified precisely into different segments theoretically as well as visually. This is a useful website to teach students in school with interactive tools to view the various human internal systems in 2D as well as 3D.

3. KissPNG

Kisspng useful websites

This website provides free high definition images without the background. Search for more than one million PNG images absolutely free for your brochures, banners, websites, etc. The website provides unlimited downloads.

4. Pixlr

Edit pictures without Photoshop or any other high-end software. Pixlr is an easy to use software that doesn’t need installation and is absolutely free. You can edit your images in your browser or download the app on your phone to edit pictures without any complicated tools!

5. Pixabay

Pixabay useful websites

Shutterstock can be really expensive at times so here comes Pixabay to save your day. Million of royalty free images to download along with illustrations, videos, and vector graphics. All of it free! Suitable for beginner level graphic designers or non-designers who want to dabble in basic designing.

6. Privnote

Privnote useful websites

Send a note that can self-destruct after it’s read. Emails sometimes cannot be private enough and sometimes you just forget to delete sensitive information. This is an easy to use website to make sure there is no data recovery of intensely sensitive notes.

7. Skyscanner

Skyscanner useful websites

If you’re on a budget or if you’re trying to save money on your travels, this is the perfect site for you. This is a perfect website to find cheaper flights that even Google shows on its list. Apart from the flights it also shows cheaper hotels to stay in or a pocket-friendly car to hire.

8. Spotahome

Spotahome useful websites

Apartments or rooms for renting mid to long term. This site has people check for the properties personally, has a virtual video tour of the entire apartment as well as HD pictures of the properties. Currently, they are covering almost 30 cities in Europe. Suited best for students and backpackers in Europe.

9. Uniplaces

Uniplaces useful websites

Another great website for students looking for affordable accommodations in Europe with a bigger list of cities and an even more helpful staff. The site is also affiliated with various colleges and universities in Europe to provide certain discounts to their students. They also provide free help for the first 7 days.

10. Bachelor Studies

Bachelorstudies useful websites

This website finds a Bachelor’s Program or Degree for you according to your preference of the country, language, cost, part-time or full time and much more. It also gives a list of top destinations to study in your home country. It also enquires details about the course from your side if you create an account & add the universities in your interested list.

11. Computer Hope

Computer hope useful websites

Keyboard shortcuts can drastically increase your productivity. Computer Hope teaches the basic shortcut keys as well as lists the shortcuts for various software that are used by an average computer user.

12. Lucidchart

Lucidchart useful websites

An easy to use website that converts your data into a neat diagram. A great way to make flowcharts, task flows, and even wireframes. You do not need to install any software, just get things done on the website along with collaborations with your team or colleagues using any device, across any platforms.

13. Swole

Swole useful websites

The automatic diet planner. Lets you plan your grocery list, your meals according to calories you need to consume and has a food bank that shows the detailed nutrition list of all kinds of food. Helps you keep a proper diet and divides it into different frequencies of meals according to your liking.

14. Mega

Mega useful websites

Dropbox and Google Drive limit your storage online after a mere 15 GBs. Mega gives you 50GB of free storage after you create an account. It is secure and runs on all the platforms.

15. Tinycards By Duolingo

Tinycards Duolingo useful websites

Flashcards make learning easier, especially when it comes to languages. This fun website by Duolingo is a simpler version to remember words using flashcards and allows you to create your own deck on any topic of your choice with either text or pictures!

16. Diff Checker

Diff Checker useful websites

A perfect way to find out if your document has been changed by someone else. It allows you to find the differences between two pieces of text and compare them. Just got an updated piece back from your editor? Use Diff Checker to find out exactly what your editor changed.

17. Dillinger

Dillinger useful websites

Dillinger is an online cloud-enabled HTML5 Markdown editor. It is mobile friendly and provides offline storage. Using Dillinger, you can export clean markdown to HTML, drag and drop images and more. Dillinger is perfect for bloggers and developers alike.

18. Fast

Fast useful websites

Be it a mobile hotspot, an airport Wi-Fi, mobile data or your office broadband. Check the current speed of your internet connection on this website that is minimal and to-the-point.

19. Dictation.io

Dictate your emails and documents in Google Chrome with any language you speak. Dictation.io accurately transcribes speech to text in real time. It allows you to add smileys, paragraphs and even punctuations using the voice commands!

20. FlightStats

Flightstats useful websites

Be it a globetrotter, student, businessman or just a concerned parent. This website allows you to track any flight all over the world from anywhere. Just enter the flight number and get the real-time location or status of the flight!

21. Every Time Zone

Everytimezone useful websites

Calculating different time zones can be a headache most of the time. This site is a less confusing view of the world’s time zones with reference to yours.

22. PDF Escape

PDF Escape useful websites

This PDF editor lets you easily edit a PDF or a PDF form online without using Adobe Acrobat or any other software. Did we mention that it’s free?

23. Infogram

This website not only allows you to create stunning infographics but also lets you create charts, reports, social media visuals and a custom dashboard to keep track of the inner as well as outer workings of your business.

24. Snopes

Snopes useful websites

If you are the one looking for online deals to save money then this website is perfect for you. Snopes allows you to find out whether that email deal received is real or just another scam!

25. Slide.ly

A do-it-yourself tool to make your own promotional videos. It is the only digital video service that provides you with premium video footages, licensed music, and amazing copy to create instant promotional videos at affordable prices.

Be a Part of the Web Culture

These are just some websites on the web you can use to cover little needs here and there. The internet machine chugs on every day, so bookmark our previous collection of the most useful websites.

Read the full article: 25 More Insanely Useful Websites You Might Need Someday

via MakeUseOf.com
25 More Insanely Useful Websites You Might Need Someday

Brownells Launches Exclusive LMT M203 37mm Launcher

GRINNELL, Iowa-(Ammoland.com)- Brownells adds some real pop to an already-explosive lineup, making its exclusive Lewis Machine & Tool M203 37mm Launchers available for sale.

Unveiled during the 2018 NRA Annual Meetings & Exhibits in early May in Dallas, Texas, the Brownells M203 37mm Launchers are close copies of M203 40mm Grenade Launchers first issued to the U.S. military in 1969, and currently in military use worldwide.

Manufactured by Lewis Machine & Tool, the M203 37mm launchers attach to standard Government rifle and carbine length barrels on AR-15 style rifles, sold separately, with .625″ front diameter and a GI-compatible barrel nut, including various models of Brownells Retro Rifles chambered in 5.56.

Brownells Launches Exclusive LMT M203 37mm Launcher
Brownells – LMT M203 37mm Launcher

“Lewis Machine & Tool has been a longtime supplier of the 40mm M203 Grenade Launcher to the US Military, and now Brownells is proud to partner with LMT to offer a 37mm M203 Flare Launcher to the firearms enthusiast, collector and reenactor,” said Brownells Director of Product Management Paul Levy. “Neither a destructive device or controlled FFL item, owning an authentic M203 has never been more straightforward and accessible.”

Because of their smaller, smooth bores, and inability to accept 40mm projectiles, the 37mm launchers do not require an FFL for purchase, nor any special registration to own.

Fireworks, flares, smoke rounds, “bird bombs” and other 37mm launcher ammo is widely available from several sources.

In addition to the launchers themselves, Brownells also offers accessories and the required mounting kits for the 37mm M203 Launchers:

To see the M203 37mm Launchers and accessories, visit the M203 “Launch The New You” page at Brownells.


About BrownellsBrownells : http://goo.gl/cJ1FMM

Serious About Firearms Since 1939™, Brownells is the world’s leading source for guns, gun parts and accessories, ammunition, gunsmithing tools and survival gear. With a large selection of both common and hard-to-find items, and an extensive collection of videos, articles, and gun schematics, Brownells is the expert for everything shooting-related. Committed to maintaining our great traditions, Brownells has more, does more and knows more – and guarantees it all, Forever. For more information or to place an order, call 800-741-0015 or visit Brownells.com. Stay up-to-date with Brownells on YouTube, Facebook, Twitter and Instagram.

The post Brownells Launches Exclusive LMT M203 37mm Launcher appeared first on AmmoLand.com.

via AmmoLand.com
Brownells Launches Exclusive LMT M203 37mm Launcher

CrunchMatch is open for business at Disrupt SF 2018

Holy smokes! Disrupt San Francisco 2018, which takes place September 5-7, is less than one month away. We have important news for anyone who purchased Startup Alley, Founder, Investor or Insider passes: CrunchMatch — your gateway to efficient networking — is officially open!

If you haven’t yet grabbed a pass to Disrupt SF 2018, it’s not too late to jump on the CrunchMatch train. Startup Alley, Founder and Investor passes are still available. Buy them right here.

Lest you’ve forgotten, CrunchMatch is the free business match-making service at Disrupt. Powered by Brella, this platform curates and connects early-stage startup founders and investors who share similar business interests and profiles.

The matching process is in full swing, so if you’re registered, keep your eyes peeled on your inbox for an invitation to create a CrunchMatch profile. For example, founders provide information about their early-stage startup — its tech category, funding stage, where it’s located and its current funding status. Investor profiles outline specific investment categories, the funding stage and preferred geographic locations. CrunchMatch takes all that information and works a bit of algorithmic voodoo to match compatible founders and investors based on the information they provide.

Once you receive those recommendations, the networking ball lands in your court. Send, receive, accept and decline invitations, set up appointment meetings and reserve private meeting space at the CrunchMatch meeting booth at Disrupt.

CrunchMatch also lets you act quickly in the heat of the moment. Say you see a particularly promising startup compete in Startup Battlefield. Use CrunchMatch to send an invitation and schedule a meeting in minutes. Boom! Hey, it worked for Michael Kocan, an early-stage investor at Trend Discovery.

“I get the most value from Disrupt at the intersection of CrunchMatch and Startup Battlefield. I can quickly schedule a meeting for later that day. I had over 35 meetings with startups that I pre-vetted using CrunchMatch, and I made a significant investment in one.”

He’s not the only satisfied customer. Last year at Disrupt SF 2017, CrunchMatch facilitated more than 1,300 meetings and 97 percent of participants said they’d use the service again. With more than 10,000 attendees coming to Disrupt SF 2018, we fully expect to triple the number of meetings.

Disrupt San Francisco 2018 takes place September 5-7. Be sure to fill out your profiles when you receive your invitation. Or buy your Founder or Investor passes now. You have only three days at Disrupt SF to make potentially life-changing connections. Let CrunchMatch simplify your networking — for free.


via TechCrunch
CrunchMatch is open for business at Disrupt SF 2018

A beginner’s guide to database multitenancy

Introduction In software terminology, multitenancy is an architectural pattern which allows you to isolate customers even if they are using the same hardware or software components. Multitenancy has become even more attractive with the widespread adoption of cloud computing. A relational database system provides a hierarchy structure of objects which, typically, looks like this: catalog … Continue reading A beginner’s guide to database multitenancy

The post A beginner’s guide to database multitenancy appeared first on Vlad Mihalcea.

via Planet MySQL
A beginner’s guide to database multitenancy

Multi-Cloud SaaS Applications: Speed + Availability = Success!

In this blog post, we talk about how to run applications across multiple clouds (i.e. AWS, Google Cloud, Microsoft Azure) using Continuent Clustering. You want your business-critical applications to withstand node, datacenter, availability-zone or regional failures. For SaaS apps, you also want to bring data close to your application users for faster response times and a better user experience. With cross-cloud capability, Continuent also helps avoid lock-in to any particular cloud provider

The key to success for the database layer is to be available and respond rapidly.

From both a business and operational perspective, spreading the application across cloud environments from different vendors provides significant protection against vendor-specific outages and vendor lock-in. Running on multiple platforms provides greater bargaining leverage with each vendor, because they do not have a monopoly on your cloud operations.

Continuent Clustering is flexible and platform-agnostic, which means it allows me to run across many different environments. You may mix-and-match any and all together (i.e. one or more clusters of 3 nodes each per environment), which means I can have a cluster spanning AWS, GCS, Azure and even include my bare-metal datacenter. For cost savings, test/dev/etc. can be put on VM’s, Docker containers or even VirtualBox.

There are many challenges to running an application over large distances, including network latency for reads and getting local writes distributed to other regions.

Continuent Clustering provides a cohesive solution which addresses the various concerns when running a geo-distributed application.

Let’s look at the various factors, and how each is handled:

Be available

  • (local) – when looked at from a local perspective, this is considered high availability (HA). If the MySQL database, which is handling writes (and reads) should become unavailable, automatically switch to another server with the same information and proceed to serve writes and reads to the application layer with as little down-time as possible.
  • (global) – when looked at from a global perspective, this is called disaster recovery (DR). Should an entire site, region, availability zone or even cloud become unavailable, allow another site with the same information to serve writes and reads to the application layer with as little down-time as possible.
  • (global) – the Tungsten Replicator is cluster-aware, which means that in the event of the complete loss of a remote node to obtain data from, the Replicator is able to automatically switch to another source node and pick up where it left off.
  • (global) – the Tungsten Connector is cluster- and site-aware, and is able to route both read and write requests to both local and remote resources. When the Connector is installed directly on an application server, a Multimaster cluster topology can withstand the loss of the entire database layer at one site by redirecting reads and writes to another region.

Respond rapidly to requests

  • (local) – by using the failover replicas as read sources, we are able to offload the requests from the master, freeing up valuable resources on the master (i.e. CPU, memory, disk I/O, network bandwidth, etc.). This has the double effect of increasing performance on the write master and improving response time for reads.
  • (global) – employing active/active multimaster clustering, writes to each region are replicated to all other regions. This then makes the data available for local reads, so the database layer is able to respond much more quickly to requests for specific data which otherwise would have to be fetched from a remote site over the WAN, adding precious milliseconds to every query.
  • (global) – the built-in Tungsten Replicator provides loosely-coupled asynchronous data transfer both to local read replicas as well as to all remote sites. Given that WAN connections sometimes have high latency and even complete disconnects, the Replicator is able to track every event, pause when the link is down and resume when the link becomes available.

All of the above facets combine to make a polished diamond of a solution, fit for your company’s worldwide enterprise-quality deployment!

If you are interested in running a proof-of-concept, please contact us now!

via Planet MySQL
Multi-Cloud SaaS Applications: Speed + Availability = Success!

Too much of this protein may drive kidney cancer

Scientists have uncovered a potential therapeutic target for kidney cancers that have a common genetic change.

Scientists have known this genetic change can lead to an overabundance of blood vessels, which help feed nutrients to the tumors, but the latest finding shows a potential new cancer-driving pathway.

More than 90 percent of the most common type of kidney cancer have a genetic change that leads to the loss of an important tumor suppressor gene called VHL.

In the study, which appears in Science, researchers identify a new downstream effect of this genetic change that is helping to drive kidney cancer: A protein called ZHX2 over-accumulates in these cells and helps to turn on other signals involved in cancerous growth.

The findings suggest that the protein is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer.

Losing VHL

“If you lose VHL, you will accumulate lots of this ZHX2 protein, which will turn on signals that promote kidney cancer,” says Qing Zhang, an assistant professor in the pathology & laboratory medicine and pharmacology department at the UNC School of Medicine. “This protein could be a potential therapeutic target used to treat kidney cancer on its own or in combination. The next step is to try to figure out how we can target it therapeutically.”

Clear cell renal cell carcinoma accounts for about 70 percent of all cases of kidney cancer, researchers report. Approximately 90 percent of patients with clear cell renal cell carcinoma have genetic mutations or alterations that cause them to lose the function of VHL. When the function of VHL is gone, cells can accumulate signals that trigger blood vessels to grow.

“VHL is the most important tumor suppressor in clear cell renal cell carcinoma,” Zhang says. “There are extensive reports showing that from initiation to tumor progression to metastasis—during the whole process of kidney cancer development—VHL plays a central role.

“It is important to understand how the VHL loss contributes to kidney cancer, and how we can therapeutically target the downstream effects of this loss in kidney cancer.”

“We wanted to understand, once VHL is lost, what else in kidney cancer cells is promoting oncogenesis?”

There are US Food and Drug Administration-approved drugs that block cell signals involved in abnormal blood vessel production—which is a downstream effect of VHL loss—that are part of the standard of care for clear cell renal cell carcinoma. Patients can show little response to these drugs or can develop resistance, so Zhang and his colleagues wanted to search for other targets that accumulate in cells lacking VHL function that help to drive the abnormal cancerous growth.

“We wanted to understand, once VHL is lost, what else in kidney cancer cells is promoting oncogenesis?” Zhang says. “Therapeutically speaking, we’re trying to understand how we can target these novel signaling pathways, once we identify them.”

Too much ZHX2

The researchers created a screening technique to discover new molecules that might help drive cancer when VHL is lost. This led them to determine that kidney cancer cells lacking VHL usually had more ZHX2. By eliminating ZHX2 from their laboratory models, they inhibited cancer cell growth, invasion, and the cancer’s spread. In addition, they saw that it was involved with signals that can help cancer cells grow.

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There have been major advances in the treatment of kidney cancer with the development of molecularly-targeted therapies and immune-based treatments, says William Kim, associate professor of medicine and genetics at the UNC School of Medicine. However, additional treatments are needed to reach more patients with metastatic disease.

“The vast majority of kidney cancers have mutations in VHL, so it makes it a very important gene to investigate,” Kim says. “In the last decade or more, we’ve had quite a number of major treatment advances in kidney cancer. There are nearly a dozen FDA-approved treatments now for this disease, but many of them are similar.

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“Studies like this are important because they delineate the underlying biology of kidney cancer and identify novel, distinct pathways to develop drugs against.”

A US Department of Defense Career Development Award, the University Cancer Research Fund, and the National Cancer Institute funded the work.

Source: UNC-Chapel Hill

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Too much of this protein may drive kidney cancer